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A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry
Binding to the primary receptor, CD4, triggers conformational changes in the metastable envelope glycoprotein (Env) trimer (gp120(3)/gp41(3)) of human immunodeficiency virus (HIV-1) that are important for virus entry into host cells. These changes include an “opening” of the trimer, creation of a bi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231716/ https://www.ncbi.nlm.nih.gov/pubmed/25174000 http://dx.doi.org/10.1038/nchembio.1623 |