Efficient in silico exploration of RNA interhelical conformations using Euler angles and WExplore

HIV-1 TAR RNA is a two-helix bulge motif that plays a critical role in HIV viral replication and is an important drug target. However, efforts at designing TAR inhibitors have been challenged by its high degree of structural flexibility, which includes slow large-amplitude reorientations of its heli...

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Detalles Bibliográficos
Autores principales: Dickson, Alex, Mustoe, Anthony M., Salmon, Loïc, Brooks, Charles L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231733/
https://www.ncbi.nlm.nih.gov/pubmed/25294827
http://dx.doi.org/10.1093/nar/gku799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231733/
https://www.ncbi.nlm.nih.gov/pubmed/25294827
http://dx.doi.org/10.1093/nar/gku799

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