Human PrimPol mutation associated with high myopia has a DNA replication defect

PrimPol is a primase-polymerase found in humans, and other eukaryotes, involved in bypassing lesions encountered during DNA replication. PrimPol employs both translesion synthesis and repriming mechanisms to facilitate lesion bypass by the replisome. PrimPol has been reported to be a potential susce...

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Detalles Bibliográficos
Autores principales: Keen, Benjamin A., Bailey, Laura J., Jozwiakowski, Stanislaw K., Doherty, Aidan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231748/
https://www.ncbi.nlm.nih.gov/pubmed/25262353
http://dx.doi.org/10.1093/nar/gku879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231748/
https://www.ncbi.nlm.nih.gov/pubmed/25262353
http://dx.doi.org/10.1093/nar/gku879

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