Telomere stability and development of ctc1 mutants are rescued by inhibition of EJ recombination pathways in a telomerase-dependent manner

The telomeres of linear eukaryotic chromosomes are protected by caps consisting of evolutionarily conserved nucleoprotein complexes. Telomere dysfunction leads to recombination of chromosome ends and this can result in fusions which initiate chromosomal breakage–fusion–bridge cycles, causing genomic...

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Detalles Bibliográficos
Autores principales: Amiard, Simon, Olivier, Margaux, Allain, Elisabeth, Choi, Kyuha, Smith-Unna, Richard, Henderson, Ian R., White, Charles I., Gallego, Maria Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231758/
https://www.ncbi.nlm.nih.gov/pubmed/25274733
http://dx.doi.org/10.1093/nar/gku897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231758/
https://www.ncbi.nlm.nih.gov/pubmed/25274733
http://dx.doi.org/10.1093/nar/gku897

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