Regulation of BCL-X splicing reveals a role for the polypyrimidine tract binding protein (PTBP1/hnRNP I) in alternative 5′ splice site selection

Alternative splicing (AS) modulates many physiological and pathological processes. For instance, AS of the BCL-X gene balances cell survival and apoptosis in development and cancer. Herein, we identified the polypyrimidine tract binding protein (PTBP1) as a direct regulator of BCL-X AS. Overexpressi...

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Detalles Bibliográficos
Autores principales: Bielli, Pamela, Bordi, Matteo, Biasio, Valentina Di, Sette, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231771/
https://www.ncbi.nlm.nih.gov/pubmed/25294838
http://dx.doi.org/10.1093/nar/gku922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231771/
https://www.ncbi.nlm.nih.gov/pubmed/25294838
http://dx.doi.org/10.1093/nar/gku922

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