Cargando…

Regulation of BCL-X splicing reveals a role for the polypyrimidine tract binding protein (PTBP1/hnRNP I) in alternative 5′ splice site selection

Alternative splicing (AS) modulates many physiological and pathological processes. For instance, AS of the BCL-X gene balances cell survival and apoptosis in development and cancer. Herein, we identified the polypyrimidine tract binding protein (PTBP1) as a direct regulator of BCL-X AS. Overexpressi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bielli, Pamela, Bordi, Matteo, Biasio, Valentina Di, Sette, Claudio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231771/ https://www.ncbi.nlm.nih.gov/pubmed/25294838 http://dx.doi.org/10.1093/nar/gku922

Ejemplares similares

The Role of Polypyrimidine Tract-Binding Proteins and Other hnRNP Proteins in Plant Splicing Regulation
por: Wachter, Andreas, et al.
Publicado: (2012)

hnRNP A1 and hnRNP F Modulate the Alternative Splicing of Exon 11 of the Insulin Receptor Gene
por: Talukdar, Indrani, et al.
Publicado: (2011)

hnRNP A1 and secondary structure coordinate alternative splicing of Mag
por: Zearfoss, N. Ruth, et al.
Publicado: (2013)

Control of alternative splicing by forskolin through hnRNP K during neuronal differentiation
por: Cao, Wenguang, et al.
Publicado: (2012)

hnRNP A1 Regulates Alternative Splicing of Tau Exon 10 by Targeting 3′ Splice Sites
por: Liu, Yongchao, et al.
Publicado: (2020)

Intronic Binding Sites for hnRNP A/B and hnRNP F/H Proteins Stimulate Pre-mRNA Splicing
por: Martinez-Contreras, Rebeca, et al.
Publicado: (2006)

HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA
por: Rahman, Mohammad Alinoor, et al.
Publicado: (2013)

Multiple determinants of splicing repression activity in the polypyrimidine tract binding proteins, PTBP1 and PTBP2
por: Keppetipola, Niroshika M., et al.
Publicado: (2016)

Polypyrimidine tract binding proteins PTBP1 and PTBP2 interact with distinct proteins under splicing conditions
por: Pina, Jeffrey M., et al.
Publicado: (2022)

HnRNP L and L-like cooperate in multiple-exon regulation of CD45 alternative splicing
por: Preußner, Marco, et al.
Publicado: (2012)

Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1
por: Jones, Alisha N., et al.
Publicado: (2022)

The Role of Alternative Splicing Factors hnRNP G and Fox-2 in the Progression and Prognosis of Esophageal Cancer
por: Zheng, Yuanyuan, et al.
Publicado: (2022)

Polypyrimidine Tract Binding Protein (hnRNP I) Is Possibly a Conserved Modulator of miRNA-Mediated Gene Regulation
por: Engels, Bart, et al.
Publicado: (2012)

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution
por: König, Julian, et al.
Publicado: (2010)

Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms
por: Nazim, Mohammad, et al.
Publicado: (2017)

An hnRNP-like RNA-binding protein affects alternative splicing by in vivo interaction with transcripts in Arabidopsis thaliana
por: Streitner, Corinna, et al.
Publicado: (2012)

HnRNP A1 controls a splicing regulatory circuit promoting mesenchymal-to-epithelial transition
por: Bonomi, Serena, et al.
Publicado: (2013)

Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells
por: Calabretta, Sara, et al.
Publicado: (2015)

Global identification of hnRNP A1 binding sites for SSO-based splicing modulation
por: Bruun, Gitte H., et al.
Publicado: (2016)

Paralogs hnRNP L and hnRNP LL Exhibit Overlapping but Distinct RNA Binding Constraints
por: Smith, Sarah A., et al.
Publicado: (2013)

The hnRNP F/H homologue of Trypanosoma brucei is differentially expressed in the two life cycle stages of the parasite and regulates splicing and mRNA stability
por: Gupta, Sachin Kumar, et al.
Publicado: (2013)

40S hnRNP particles are a novel class of nuclear biomolecular condensates
por: Domanski, Michal, et al.
Publicado: (2022)

Systematic Analysis of Gene Expression Profiles Controlled by hnRNP Q and hnRNP R, Two Closely Related Human RNA Binding Proteins Implicated in mRNA Processing Mechanisms
por: Cappelli, Sara, et al.
Publicado: (2018)

A cytoplasmic quaking I isoform regulates the hnRNP F/H-dependent alternative splicing pathway in myelinating glia
por: Mandler, Mariana D., et al.
Publicado: (2014)

TCF3 alternative splicing controlled by hnRNP H/F regulates E-cadherin expression and hESC pluripotency
por: Yamazaki, Takashi, et al.
Publicado: (2018)

PKC Regulates YAP Expression through Alternative Splicing of YAP 3′UTR Pre-mRNA by hnRNP F
por: Chu, Wing-Keung, et al.
Publicado: (2021)

RBMX suppresses tumorigenicity and progression of bladder cancer by interacting with the hnRNP A1 protein to regulate PKM alternative splicing
por: Yan, Qiuxia, et al.
Publicado: (2021)

hnRNP L controls HPV16 RNA polyadenylation and splicing in an Akt kinase-dependent manner
por: Kajitani, Naoko, et al.
Publicado: (2017)

The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages
por: West, Kelsi O., et al.
Publicado: (2019)

hnRNP A1B, a Splice Variant of HNRNPA1, Is Spatially and Temporally Regulated
por: Gagné, Myriam, et al.
Publicado: (2021)

Requirement of splicing factor hnRNP A2B1 for tumorigenesis of melanoma stem cells
por: Chu, Mengqi, et al.
Publicado: (2021)

Heterogeneous Nuclear Ribonucleoprotein A1 (hnRNP A1) and hnRNP A2 Inhibit Splicing to Human Papillomavirus 16 Splice Site SA409 through a UAG-Containing Sequence in the E7 Coding Region
por: Zheng, Yunji, et al.
Publicado: (2020)

Suppression of HPV-16 late L1 5′-splice site SD3632 by binding of hnRNP D proteins and hnRNP A2/B1 to upstream AUAGUA RNA motifs
por: Li, Xiaoze, et al.
Publicado: (2013)

Characterization of the RNA recognition mode of hnRNP G extends its role in SMN2 splicing regulation
por: Moursy, Ahmed, et al.
Publicado: (2014)

Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing
por: Thompson, Matthew G., et al.
Publicado: (2018)

Reciprocal regulation of hnRNP C and CELF2 through translation and transcription tunes splicing activity in T cells
por: Mallory, Michael J, et al.
Publicado: (2020)

HnRNP L represses cryptic exons
por: McClory, Sean P., et al.
Publicado: (2018)

HnRNP Pathologies in Frontotemporal Lobar Degeneration
por: Jiang, Xinwa, et al.
Publicado: (2023)

Molecular population dynamics of DNA structures in a bcl-2 promoter sequence is regulated by small molecules and the transcription factor hnRNP LL
por: Cui, Yunxi, et al.
Publicado: (2014)

Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development
por: Shilo, Asaf, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_r54k5p131vm0fj5l3mkkgfroct