Rapidly fatal Askin's tumor: a case report and literature review
An 18-year-old male presented with a mass in the right anterior chest wall. Chest Computed tomography revealed a heterogenous mass of 19X13 cm in the right hemithorax with areas of necrosis. There was associated pleural effusion and infiltration of the soft parts of the chest wall. Bronchoscopy show...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The African Field Epidemiology Network
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232025/ https://www.ncbi.nlm.nih.gov/pubmed/25404964 http://dx.doi.org/10.11604/pamj.2014.18.104.4549 |
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author | Laine, Mustapha Ghorfi, Ismail Abderrahmani Lambatten, Dalal Kettani, Fouad Abid, Ahmed |
author_facet | Laine, Mustapha Ghorfi, Ismail Abderrahmani Lambatten, Dalal Kettani, Fouad Abid, Ahmed |
author_sort | Laine, Mustapha |
collection | PubMed |
description | An 18-year-old male presented with a mass in the right anterior chest wall. Chest Computed tomography revealed a heterogenous mass of 19X13 cm in the right hemithorax with areas of necrosis. There was associated pleural effusion and infiltration of the soft parts of the chest wall. Bronchoscopy showed a tumor in middle lobe bronchus. CT guided biopsy of the mass was performed. Histological examination showed small round tumor cells with scanty cytoplasm, the nuclei are large and hyperchromatic. The tumor cells were positive for CD99 and neuron specific enolase, negative for cytokeratin, leukocyte common antigen and myogenin. Based on these histologic and immunohistochemical findings, the diagnosis of askin's tumor was made. The extension assessment was negative and the patient was given chemotherapy. Two months later, our patient died. Askin's tumor is a rare, highly malignant tumor affecting children and young adults. It is classified as primitive neuroectodermal tumor of the thoracopulmonary region. Prognosis remains poor. In our case, several prognostic factors may explain the shirt ‘term survival, despite no distant metastasis were found: important tumor size, impossibility of surgical treatment and pleural effusion. |
format | Online Article Text |
id | pubmed-4232025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The African Field Epidemiology Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-42320252014-11-17 Rapidly fatal Askin's tumor: a case report and literature review Laine, Mustapha Ghorfi, Ismail Abderrahmani Lambatten, Dalal Kettani, Fouad Abid, Ahmed Pan Afr Med J Case Report An 18-year-old male presented with a mass in the right anterior chest wall. Chest Computed tomography revealed a heterogenous mass of 19X13 cm in the right hemithorax with areas of necrosis. There was associated pleural effusion and infiltration of the soft parts of the chest wall. Bronchoscopy showed a tumor in middle lobe bronchus. CT guided biopsy of the mass was performed. Histological examination showed small round tumor cells with scanty cytoplasm, the nuclei are large and hyperchromatic. The tumor cells were positive for CD99 and neuron specific enolase, negative for cytokeratin, leukocyte common antigen and myogenin. Based on these histologic and immunohistochemical findings, the diagnosis of askin's tumor was made. The extension assessment was negative and the patient was given chemotherapy. Two months later, our patient died. Askin's tumor is a rare, highly malignant tumor affecting children and young adults. It is classified as primitive neuroectodermal tumor of the thoracopulmonary region. Prognosis remains poor. In our case, several prognostic factors may explain the shirt ‘term survival, despite no distant metastasis were found: important tumor size, impossibility of surgical treatment and pleural effusion. The African Field Epidemiology Network 2014-05-30 /pmc/articles/PMC4232025/ /pubmed/25404964 http://dx.doi.org/10.11604/pamj.2014.18.104.4549 Text en © Mustapha Laine et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Laine, Mustapha Ghorfi, Ismail Abderrahmani Lambatten, Dalal Kettani, Fouad Abid, Ahmed Rapidly fatal Askin's tumor: a case report and literature review |
title | Rapidly fatal Askin's tumor: a case report and literature review |
title_full | Rapidly fatal Askin's tumor: a case report and literature review |
title_fullStr | Rapidly fatal Askin's tumor: a case report and literature review |
title_full_unstemmed | Rapidly fatal Askin's tumor: a case report and literature review |
title_short | Rapidly fatal Askin's tumor: a case report and literature review |
title_sort | rapidly fatal askin's tumor: a case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232025/ https://www.ncbi.nlm.nih.gov/pubmed/25404964 http://dx.doi.org/10.11604/pamj.2014.18.104.4549 |
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