Rapidly fatal Askin's tumor: a case report and literature review

An 18-year-old male presented with a mass in the right anterior chest wall. Chest Computed tomography revealed a heterogenous mass of 19X13 cm in the right hemithorax with areas of necrosis. There was associated pleural effusion and infiltration of the soft parts of the chest wall. Bronchoscopy show...

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Autores principales: Laine, Mustapha, Ghorfi, Ismail Abderrahmani, Lambatten, Dalal, Kettani, Fouad, Abid, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232025/
https://www.ncbi.nlm.nih.gov/pubmed/25404964
http://dx.doi.org/10.11604/pamj.2014.18.104.4549
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author Laine, Mustapha
Ghorfi, Ismail Abderrahmani
Lambatten, Dalal
Kettani, Fouad
Abid, Ahmed
author_facet Laine, Mustapha
Ghorfi, Ismail Abderrahmani
Lambatten, Dalal
Kettani, Fouad
Abid, Ahmed
author_sort Laine, Mustapha
collection PubMed
description An 18-year-old male presented with a mass in the right anterior chest wall. Chest Computed tomography revealed a heterogenous mass of 19X13 cm in the right hemithorax with areas of necrosis. There was associated pleural effusion and infiltration of the soft parts of the chest wall. Bronchoscopy showed a tumor in middle lobe bronchus. CT guided biopsy of the mass was performed. Histological examination showed small round tumor cells with scanty cytoplasm, the nuclei are large and hyperchromatic. The tumor cells were positive for CD99 and neuron specific enolase, negative for cytokeratin, leukocyte common antigen and myogenin. Based on these histologic and immunohistochemical findings, the diagnosis of askin's tumor was made. The extension assessment was negative and the patient was given chemotherapy. Two months later, our patient died. Askin's tumor is a rare, highly malignant tumor affecting children and young adults. It is classified as primitive neuroectodermal tumor of the thoracopulmonary region. Prognosis remains poor. In our case, several prognostic factors may explain the shirt ‘term survival, despite no distant metastasis were found: important tumor size, impossibility of surgical treatment and pleural effusion.
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spelling pubmed-42320252014-11-17 Rapidly fatal Askin's tumor: a case report and literature review Laine, Mustapha Ghorfi, Ismail Abderrahmani Lambatten, Dalal Kettani, Fouad Abid, Ahmed Pan Afr Med J Case Report An 18-year-old male presented with a mass in the right anterior chest wall. Chest Computed tomography revealed a heterogenous mass of 19X13 cm in the right hemithorax with areas of necrosis. There was associated pleural effusion and infiltration of the soft parts of the chest wall. Bronchoscopy showed a tumor in middle lobe bronchus. CT guided biopsy of the mass was performed. Histological examination showed small round tumor cells with scanty cytoplasm, the nuclei are large and hyperchromatic. The tumor cells were positive for CD99 and neuron specific enolase, negative for cytokeratin, leukocyte common antigen and myogenin. Based on these histologic and immunohistochemical findings, the diagnosis of askin's tumor was made. The extension assessment was negative and the patient was given chemotherapy. Two months later, our patient died. Askin's tumor is a rare, highly malignant tumor affecting children and young adults. It is classified as primitive neuroectodermal tumor of the thoracopulmonary region. Prognosis remains poor. In our case, several prognostic factors may explain the shirt ‘term survival, despite no distant metastasis were found: important tumor size, impossibility of surgical treatment and pleural effusion. The African Field Epidemiology Network 2014-05-30 /pmc/articles/PMC4232025/ /pubmed/25404964 http://dx.doi.org/10.11604/pamj.2014.18.104.4549 Text en © Mustapha Laine et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Laine, Mustapha
Ghorfi, Ismail Abderrahmani
Lambatten, Dalal
Kettani, Fouad
Abid, Ahmed
Rapidly fatal Askin's tumor: a case report and literature review
title Rapidly fatal Askin's tumor: a case report and literature review
title_full Rapidly fatal Askin's tumor: a case report and literature review
title_fullStr Rapidly fatal Askin's tumor: a case report and literature review
title_full_unstemmed Rapidly fatal Askin's tumor: a case report and literature review
title_short Rapidly fatal Askin's tumor: a case report and literature review
title_sort rapidly fatal askin's tumor: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232025/
https://www.ncbi.nlm.nih.gov/pubmed/25404964
http://dx.doi.org/10.11604/pamj.2014.18.104.4549
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