Plasma homocysteine and B vitamins levels in Nigerian children with nephrotic syndrome

INTRODUCTION: Available data on plasma homocysteine level in patients with nephrotic syndrome (NS) are controversial with increased, decreased and unchanged values reported. Therefore, plasma homocysteine and serum B vitamins in Nigerian children with NS were assessed in this study METHODS: Fasting...

Descripción completa

Detalles Bibliográficos
Autores principales: Orimadegun, Bose Etaniamhe, Orimadegun, Adebola Emmanuel, Ademola, Adebowale Dele, Agbedana, Emmanuel Oluyemi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232175/
https://www.ncbi.nlm.nih.gov/pubmed/25404967
http://dx.doi.org/10.11604/pamj.2014.18.107.3678
_version_ 1782344528415424512
author Orimadegun, Bose Etaniamhe
Orimadegun, Adebola Emmanuel
Ademola, Adebowale Dele
Agbedana, Emmanuel Oluyemi
author_facet Orimadegun, Bose Etaniamhe
Orimadegun, Adebola Emmanuel
Ademola, Adebowale Dele
Agbedana, Emmanuel Oluyemi
author_sort Orimadegun, Bose Etaniamhe
collection PubMed
description INTRODUCTION: Available data on plasma homocysteine level in patients with nephrotic syndrome (NS) are controversial with increased, decreased and unchanged values reported. Therefore, plasma homocysteine and serum B vitamins in Nigerian children with NS were assessed in this study METHODS: Fasting blood samples were analysed for plasma homocysteine, serum folate and B vitamins in 42 children with NS and 42 age and sex-matched healthy controls in this case control study. Data were compared between NS and control using t test and Chi square. Relationships were tested with regression analysis with p set at 0.05. RESULTS: Prevalence of hyperhomocysteinaemia, low folate and cyanocobalamin in NS was 57.1%, 14.3% and 9.5% respectively. The mean homocysteine level was significantly higher in NS than control (11.3±2.6µmol/L versus 5.5±2.3µmol/L). Also, NS had lower folate and cyanocobalamin than control: 9.1±3.9ng/mL versus 11.2±3.1ng/dL and 268.5±95.7pg/mL versus 316±117.2pg/mL respectively. Weak but significant correlation between homocysteine and serum albumin (r = 0.347), folate (r = -0.607) and vitamin B12 (r = -0.185) were found in the NS group. Significant relationship was also found between homocysteine and vitamin B12 (ß = -0.64, 95% CI = -1.20, -0.08) after controlling for folate and vitamin B6 levels. CONCLUSION: Clinically important hyperhomocysteinaemia and low B vitamins occur in Nigerian children with nephrotic syndrome. This data suggest that potential usefulness of folate and vitamin B supplementation for reducing high homocysteine levels in nephrotic syndrome need to be further investigated
format Online
Article
Text
id pubmed-4232175
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher The African Field Epidemiology Network
record_format MEDLINE/PubMed
spelling pubmed-42321752014-11-17 Plasma homocysteine and B vitamins levels in Nigerian children with nephrotic syndrome Orimadegun, Bose Etaniamhe Orimadegun, Adebola Emmanuel Ademola, Adebowale Dele Agbedana, Emmanuel Oluyemi Pan Afr Med J Research INTRODUCTION: Available data on plasma homocysteine level in patients with nephrotic syndrome (NS) are controversial with increased, decreased and unchanged values reported. Therefore, plasma homocysteine and serum B vitamins in Nigerian children with NS were assessed in this study METHODS: Fasting blood samples were analysed for plasma homocysteine, serum folate and B vitamins in 42 children with NS and 42 age and sex-matched healthy controls in this case control study. Data were compared between NS and control using t test and Chi square. Relationships were tested with regression analysis with p set at 0.05. RESULTS: Prevalence of hyperhomocysteinaemia, low folate and cyanocobalamin in NS was 57.1%, 14.3% and 9.5% respectively. The mean homocysteine level was significantly higher in NS than control (11.3±2.6µmol/L versus 5.5±2.3µmol/L). Also, NS had lower folate and cyanocobalamin than control: 9.1±3.9ng/mL versus 11.2±3.1ng/dL and 268.5±95.7pg/mL versus 316±117.2pg/mL respectively. Weak but significant correlation between homocysteine and serum albumin (r = 0.347), folate (r = -0.607) and vitamin B12 (r = -0.185) were found in the NS group. Significant relationship was also found between homocysteine and vitamin B12 (ß = -0.64, 95% CI = -1.20, -0.08) after controlling for folate and vitamin B6 levels. CONCLUSION: Clinically important hyperhomocysteinaemia and low B vitamins occur in Nigerian children with nephrotic syndrome. This data suggest that potential usefulness of folate and vitamin B supplementation for reducing high homocysteine levels in nephrotic syndrome need to be further investigated The African Field Epidemiology Network 2014-06-02 /pmc/articles/PMC4232175/ /pubmed/25404967 http://dx.doi.org/10.11604/pamj.2014.18.107.3678 Text en © Bose Etaniamhe Orimadegun et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Orimadegun, Bose Etaniamhe
Orimadegun, Adebola Emmanuel
Ademola, Adebowale Dele
Agbedana, Emmanuel Oluyemi
Plasma homocysteine and B vitamins levels in Nigerian children with nephrotic syndrome
title Plasma homocysteine and B vitamins levels in Nigerian children with nephrotic syndrome
title_full Plasma homocysteine and B vitamins levels in Nigerian children with nephrotic syndrome
title_fullStr Plasma homocysteine and B vitamins levels in Nigerian children with nephrotic syndrome
title_full_unstemmed Plasma homocysteine and B vitamins levels in Nigerian children with nephrotic syndrome
title_short Plasma homocysteine and B vitamins levels in Nigerian children with nephrotic syndrome
title_sort plasma homocysteine and b vitamins levels in nigerian children with nephrotic syndrome
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232175/
https://www.ncbi.nlm.nih.gov/pubmed/25404967
http://dx.doi.org/10.11604/pamj.2014.18.107.3678
work_keys_str_mv AT orimadegunboseetaniamhe plasmahomocysteineandbvitaminslevelsinnigerianchildrenwithnephroticsyndrome
AT orimadegunadebolaemmanuel plasmahomocysteineandbvitaminslevelsinnigerianchildrenwithnephroticsyndrome
AT ademolaadebowaledele plasmahomocysteineandbvitaminslevelsinnigerianchildrenwithnephroticsyndrome
AT agbedanaemmanueloluyemi plasmahomocysteineandbvitaminslevelsinnigerianchildrenwithnephroticsyndrome