Intranasal Administration of a Therapeutic HIV Vaccine (Vacc-4x) Induces Dose-Dependent Systemic and Mucosal Immune Responses in a Randomized Controlled Trial

BACKGROUND: Vacc-4x, a Gag p24-based therapeutic HIV vaccine, has been shown to reduce viral load set-points after intradermal administration. In this randomized controlled pilot study we investigate intranasal administration of Vacc-4x with Endocine as adjuvant. METHODS: Safety and immunogenicity w...

Descripción completa

Detalles Bibliográficos
Autores principales: Brekke, Kristin, Lind, Andreas, Holm-Hansen, Carol, Haugen, Inger Lise, Sørensen, Birger, Sommerfelt, Maja, Kvale, Dag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232368/
https://www.ncbi.nlm.nih.gov/pubmed/25398137
http://dx.doi.org/10.1371/journal.pone.0112556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232368/
https://www.ncbi.nlm.nih.gov/pubmed/25398137
http://dx.doi.org/10.1371/journal.pone.0112556

Ejemplares similares