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Intranasal Administration of a Therapeutic HIV Vaccine (Vacc-4x) Induces Dose-Dependent Systemic and Mucosal Immune Responses in a Randomized Controlled Trial

BACKGROUND: Vacc-4x, a Gag p24-based therapeutic HIV vaccine, has been shown to reduce viral load set-points after intradermal administration. In this randomized controlled pilot study we investigate intranasal administration of Vacc-4x with Endocine as adjuvant. METHODS: Safety and immunogenicity w...

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Detalles Bibliográficos
Autores principales:	Brekke, Kristin, Lind, Andreas, Holm-Hansen, Carol, Haugen, Inger Lise, Sørensen, Birger, Sommerfelt, Maja, Kvale, Dag
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232368/ https://www.ncbi.nlm.nih.gov/pubmed/25398137 http://dx.doi.org/10.1371/journal.pone.0112556

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