Hypoxia-Inducible Factors Modulate the Stemness and Malignancy of Colon Cancer Cells by Playing Opposite Roles in Canonical Wnt Signaling

This study examined the role played by hypoxia-inducible factors (HIFs) in malignant phenotype maintenance and canonical Wnt signaling. Under normoxia, we determined that both HIF-1α and HIF-2α are expressed in human colon cancer cells but not in their non-malignant counterparts. The stable knockdow...

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Detalles Bibliográficos
Autores principales: Santoyo-Ramos, Paula, Likhatcheva, María, García-Zepeda, Eduardo A., Castañeda-Patlán, M. Cristina, Robles-Flores, Martha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232394/
https://www.ncbi.nlm.nih.gov/pubmed/25396735
http://dx.doi.org/10.1371/journal.pone.0112580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232394/
https://www.ncbi.nlm.nih.gov/pubmed/25396735
http://dx.doi.org/10.1371/journal.pone.0112580

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