Dendrimeric Template of Plasmodium falciparum Histidine Rich Protein II Repeat Motifs Bearing Asp→Asn Mutation Exhibits Heme Binding and β-Hematin Formation

Plasmodium falciparum (Pf) employs a crucial PfHRPII catalyzed reaction that converts toxic heme into hemozoin. Understanding heme polymerization mechanism is the first step for rational design of new drugs, targeting this pathway. Heme binding and hemozoin formation have been ascribed to PfHRPII as...

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Detalles Bibliográficos
Autores principales: Kumari, Pinky, Sahal, Dinkar, Chauhan, Virander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232395/
https://www.ncbi.nlm.nih.gov/pubmed/25398028
http://dx.doi.org/10.1371/journal.pone.0112087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232395/
https://www.ncbi.nlm.nih.gov/pubmed/25398028
http://dx.doi.org/10.1371/journal.pone.0112087

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