Electrophilic activity-based RNA probes reveal a self-alkylating RNA for RNA labeling

Probes that form covalent bonds with RNA molecules based on their chemical reactivity would advance our ability to study the transcriptome. We developed a set of electrophilic activity-based RNA probes designed to react with unusually nucleophilic RNAs. We used these probes to identify reactive geno...

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Detalles Bibliográficos
Autores principales: McDonald, Richard I., Guilinger, John P., Mukherji, Shankar, Curtis, Edward A., Lee, Won I., Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232462/
https://www.ncbi.nlm.nih.gov/pubmed/25306441
http://dx.doi.org/10.1038/nchembio.1655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232462/
https://www.ncbi.nlm.nih.gov/pubmed/25306441
http://dx.doi.org/10.1038/nchembio.1655

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