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Hydrolysis of 2′3′-cGAMP by ENPP1 and design of non-hydrolyzable analogs
Agonists of mouse STING (TMEM173) shrink and even cure solid tumor by activating innate immunity; human STING agonists are needed to test this therapeutic hypothesis in man. The endogenous STING agonist is 2′3′-cGAMP, a 2(nd) messenger that signals the presence of cytosolic dsDNA. We report activity...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232468/ https://www.ncbi.nlm.nih.gov/pubmed/25344812 http://dx.doi.org/10.1038/nchembio.1661 |