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Hydrolysis of 2′3′-cGAMP by ENPP1 and design of non-hydrolyzable analogs

Agonists of mouse STING (TMEM173) shrink and even cure solid tumor by activating innate immunity; human STING agonists are needed to test this therapeutic hypothesis in man. The endogenous STING agonist is 2′3′-cGAMP, a 2(nd) messenger that signals the presence of cytosolic dsDNA. We report activity...

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Detalles Bibliográficos
Autores principales:	Li, Lingyin, Yin, Qian, Kuss, Pia, Maliga, Zoltan, Millán, José L., Wu, Hao, Mitchison, Timothy J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232468/ https://www.ncbi.nlm.nih.gov/pubmed/25344812 http://dx.doi.org/10.1038/nchembio.1661

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