Identification of Functionally Important Residues of the Rat P2X4 Receptor by Alanine Scanning Mutagenesis of the Dorsal Fin and Left Flipper Domains

Crystallization of the zebrafish P2X4 receptor in both open and closed states revealed conformational differences in the ectodomain structures, including the dorsal fin and left flipper domains. Here, we focused on the role of these domains in receptor activation, responsiveness to orthosteric ATP a...

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Detalles Bibliográficos
Autores principales: Tvrdonova, Vendula, Rokic, Milos B., Stojilkovic, Stanko S., Zemkova, Hana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232510/
https://www.ncbi.nlm.nih.gov/pubmed/25398027
http://dx.doi.org/10.1371/journal.pone.0112902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232510/
https://www.ncbi.nlm.nih.gov/pubmed/25398027
http://dx.doi.org/10.1371/journal.pone.0112902

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