Evaluation of sgRNA Target Sites for CRISPR-Mediated Repression of TP53

The CRISPR (clustered regularly interspaced short palindromic repeats) platform has been developed as a general method to direct proteins of interest to gene targets. While the native CRISPR system delivers a nuclease that cleaves and potentially mutates target genes, researchers have recently emplo...

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Detalles Bibliográficos
Autores principales: Lawhorn, Ingrid E. B., Ferreira, Joshua P., Wang, Clifford L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232525/
https://www.ncbi.nlm.nih.gov/pubmed/25398078
http://dx.doi.org/10.1371/journal.pone.0113232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232525/
https://www.ncbi.nlm.nih.gov/pubmed/25398078
http://dx.doi.org/10.1371/journal.pone.0113232

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