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Evaluation of sgRNA Target Sites for CRISPR-Mediated Repression of TP53
The CRISPR (clustered regularly interspaced short palindromic repeats) platform has been developed as a general method to direct proteins of interest to gene targets. While the native CRISPR system delivers a nuclease that cleaves and potentially mutates target genes, researchers have recently emplo...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232525/ https://www.ncbi.nlm.nih.gov/pubmed/25398078 http://dx.doi.org/10.1371/journal.pone.0113232 |