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Updating the mechanisms of common fragile site instability: how to reconcile the different views?

Common fragile sites (CFSs) are large chromosomal regions long identified by conventional cytogenetics as sequences prone to breakage in cells subjected to replication stress. The interest in CFSs came from their key role in the formation of DNA damage, resulting in chromosomal rearrangements. The i...

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Detalles Bibliográficos
Autores principales: Le Tallec, Benoît, Koundrioukoff, Stéphane, Wilhelm, Therese, Letessier, Anne, Brison, Olivier, Debatisse, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Basel 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232738/
https://www.ncbi.nlm.nih.gov/pubmed/25248392
http://dx.doi.org/10.1007/s00018-014-1720-2