Are common fragile sites merely structural domains or highly organized “functional” units susceptible to oncogenic stress?

Common fragile sites (CFSs) are regions of the genome with a predisposition to DNA double-strand breaks in response to intrinsic (oncogenic) or extrinsic replication stress. CFS breakage is a common feature in carcinogenesis from its earliest stages. Given that a number of oncogenes and tumor suppre...

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Detalles Bibliográficos
Autores principales: Georgakilas, Alexandros G., Tsantoulis, Petros, Kotsinas, Athanassios, Michalopoulos, Ioannis, Townsend, Paul, Gorgoulis, Vassilis G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Basel 2014
Materias:
Multi-Author Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232749/
https://www.ncbi.nlm.nih.gov/pubmed/25238782
http://dx.doi.org/10.1007/s00018-014-1717-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232749/
https://www.ncbi.nlm.nih.gov/pubmed/25238782
http://dx.doi.org/10.1007/s00018-014-1717-x

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