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Are common fragile sites merely structural domains or highly organized “functional” units susceptible to oncogenic stress?
Common fragile sites (CFSs) are regions of the genome with a predisposition to DNA double-strand breaks in response to intrinsic (oncogenic) or extrinsic replication stress. CFS breakage is a common feature in carcinogenesis from its earliest stages. Given that a number of oncogenes and tumor suppre...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Basel
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232749/ https://www.ncbi.nlm.nih.gov/pubmed/25238782 http://dx.doi.org/10.1007/s00018-014-1717-x |