A new histone deacetylase inhibitor improves liverfibrosis in BDL rats through suppression of hepatic stellate cells

BACKGROUND AND PURPOSE: Activation of hepatic stellate cells (HSCs) is a crucial step in the pathogenesis of hepatic fibrosis. Histone deacetylase (HDAC) is an attractive target in liver fibrosis because it plays a key role in gene expression and cell differentiation. We have developed a HDAC inhibi...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Ki Cheong, Park, Ji Hyun, Jeon, Jeong Yong, Kim, Sang Yong, Kim, Jung Min, Lim, Chang Yong, Lee, Tae Hyung, Kim, Hyung Kwan, Lee, Hyun Gyu, Kim, Sung Min, Kwon, Ho Jeong, Suh, Jin Suck, Kim, Seung Won, Choi, Seung Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232907/
https://www.ncbi.nlm.nih.gov/pubmed/24467283
http://dx.doi.org/10.1111/bph.12590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232907/
https://www.ncbi.nlm.nih.gov/pubmed/24467283
http://dx.doi.org/10.1111/bph.12590

Ejemplares similares