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Turoctocog alfa (NovoEight®) – from design to clinical proof of concept

Turoctocog alfa (NovoEight®) is a recombinant factor VIII (rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the N-terminus and 11 amino acids from the C-terminus of the naturally occurring B-domain. Turoctocog alfa is produced in Chinese hamster ovary (CHO) cel...

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Detalles Bibliográficos
Autores principales: Ezban, Mirella, Vad, Knud, Kjalke, Marianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232928/
https://www.ncbi.nlm.nih.gov/pubmed/24797664
http://dx.doi.org/10.1111/ejh.12366