A central role for Notch in effector CD8(+) T cell differentiation

Activated CD8(+) T cells choose between terminal effector cell (TEC) or memory precursor cell (MPC) fates. We show that Notch controls this choice. Notch promoted differentiation of immediately protective TECs and was correspondingly required for clearance of an acute influenza virus infection. Notc...

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Detalles Bibliográficos
Autores principales: Backer, Ronald A., Helbig, Christina, Gentek, Rebecca, Kent, Andrew, Laidlaw, Brian J., Dominguez, Claudia X., de Souza, Yevan S., van Trierum, Stella E., van Beek, Ruud, Rimmelzwaan, Guus F., ten Brinke, Anja, Willemsen, A. Marcel, van Kampen, Antoine H. C., Kaech, Susan M., Blander, J. Magarian, van Gisbergen, Klaas, Amsen, Derk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232996/
https://www.ncbi.nlm.nih.gov/pubmed/25344724
http://dx.doi.org/10.1038/ni.3027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232996/
https://www.ncbi.nlm.nih.gov/pubmed/25344724
http://dx.doi.org/10.1038/ni.3027

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