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miR-125b can enhance skin tumor initiation and promote malignant progression by repressing differentiation and prolonging cell survival

Previously, we identified miR-125b as a key regulator of the undifferentiated state of hair follicle stem cells. Here, we show that in both mice and humans, miR-125b is abundantly expressed, particularly at early stages of malignant progression to squamous cell carcinoma (SCC), the second most preva...

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Detalles Bibliográficos
Autores principales: Zhang, Liang, Ge, Yejing, Fuchs, Elaine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233245/
https://www.ncbi.nlm.nih.gov/pubmed/25403182
http://dx.doi.org/10.1101/gad.248377.114