Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling

Control of Gli function by Suppressor of Fused (Sufu), a major negative regulator, is a key step in mammalian Hedgehog (Hh) signaling, but how this is achieved in the nucleus is unknown. We found that Hh signaling results in reduced Sufu protein levels and Sufu dissociation from Gli proteins in the...

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Detalles Bibliográficos
Autores principales: Lin, Chuwen, Yao, Erica, Wang, Kevin, Nozawa, Yoko, Shimizu, Hirohito, Johnson, Jeffrey R., Chen, Jau-Nian, Krogan, Nevan J., Chuang, Pao-Tien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233246/
https://www.ncbi.nlm.nih.gov/pubmed/25403183
http://dx.doi.org/10.1101/gad.249425.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233246/
https://www.ncbi.nlm.nih.gov/pubmed/25403183
http://dx.doi.org/10.1101/gad.249425.114

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