Promoter Hypermethylation of the Phosphatase DUSP22 Mediates PKA-Dependent TAU Phosphorylation and CREB Activation in Alzheimer's Disease

Genetic screening in Alzheimer's disease (AD) has identified only a handful of genes that are mutated in the disorder. Thus, for a very large proportion of patients, the biology of their disease is poorly understood. Epigenetic alterations may provide an explanation in these cases. Using DNA me...

Descripción completa

Detalles Bibliográficos
Autores principales: Sanchez-Mut, Jose Vicente, Aso, Ester, Heyn, Holger, Matsuda, Tadashi, Bock, Christoph, Ferrer, Isidre, Esteller, Manel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233982/
https://www.ncbi.nlm.nih.gov/pubmed/24436131
http://dx.doi.org/10.1002/hipo.22245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233982/
https://www.ncbi.nlm.nih.gov/pubmed/24436131
http://dx.doi.org/10.1002/hipo.22245

Ejemplares similares