Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition

BET family proteins are novel therapeutic targets for cancer and inflammation and represent the first chromatin readers against which small-molecule inhibitors have been developed. First-generation BET inhibitors have shown therapeutic efficacy in preclinical models, but the consequences of sustaine...

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Detalles Bibliográficos
Autores principales: Bolden, Jessica E., Tasdemir, Nilgun, Dow, Lukas E., van Es, Johan H., Wilkinson, John E., Zhao, Zhen, Clevers, Hans, Lowe, Scott W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234106/
https://www.ncbi.nlm.nih.gov/pubmed/25242322
http://dx.doi.org/10.1016/j.celrep.2014.08.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234106/
https://www.ncbi.nlm.nih.gov/pubmed/25242322
http://dx.doi.org/10.1016/j.celrep.2014.08.025

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