Cargando…

cAMP signaling inhibits radiation-induced ATM phosphorylation leading to the augmentation of apoptosis in human lung cancer cells

BACKGROUND: The ataxia–telangiectasia mutated (ATM) protein kinase plays a central role in coordinating the cellular response to radiation-induced DNA damage. cAMP signaling regulates various cellular responses including metabolism and gene expression. This study aimed to investigate the mechanism t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cho, Eun-Ah, Kim, Eui-Jun, Kwak, Sahng-June, Juhnn, Yong-Sung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234305/ https://www.ncbi.nlm.nih.gov/pubmed/24568192 http://dx.doi.org/10.1186/1476-4598-13-36

Ejemplares similares

Inhibition of non-homologous end joining of gamma ray-induced DNA double-strand breaks by cAMP signaling in lung cancer cells
por: Noh, Sung-Eun, et al.
Publicado: (2020)

Cell-type-specific Modulation of Non-homologous End Joining of Gamma Ray-induced DNA Double-strand Breaks by cAMP Signaling in Human Cancer Cells
por: Noh, Sung-Eun, et al.
Publicado: (2020)

cAMP signaling increases histone deacetylase 8 expression via the Epac2–Rap1A–Akt pathway in H1299 lung cancer cells
por: Park, Ji-Yeon, et al.
Publicado: (2017)

Grk7 but not Grk1 undergoes cAMP-dependent phosphorylation in zebrafish cone photoreceptors and mediates cone photoresponse recovery to elevated cAMP
por: Chrispell, Jared D., et al.
Publicado: (2022)

Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4
por: Perera, Ruwan K., et al.
Publicado: (2017)

Multiple Facets of cAMP Signalling and Physiological Impact: cAMP Compartmentalization in the Lung
por: Oldenburger, Anouk, et al.
Publicado: (2012)

Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer
por: Gerlits, Oksana, et al.
Publicado: (2014)

PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination
por: Isensee, Jörg, et al.
Publicado: (2018)

Novel inhibitors of phosphorylation independent activity of GRK2 modulate cAMP signaling
por: Echeverría, Emiliana, et al.
Publicado: (2022)

Bassoon controls synaptic vesicle release via regulation of presynaptic phosphorylation and cAMP
por: Montenegro‐Venegas, Carolina, et al.
Publicado: (2022)

cAMP crosses junctions
por: Bashyam, Hema
Publicado: (2007)

Mitochondrial cAMP signaling
por: Zhang, Fan, et al.
Publicado: (2016)

cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool
por: Camarena, Vladimir, et al.
Publicado: (2017)

Axokinin phosphorylation by cAMP-dependent protein kinase is sufficient for activation of sperm flagellar motility
Publicado: (1986)

A lithium-sensitive regulator of sperm flagellar oscillation is activated by cAMP-dependent phosphorylation
Publicado: (1987)

Identification of a Protein Phosphatase-1/Phospholamban Complex That Is Regulated by cAMP-Dependent Phosphorylation
por: Vafiadaki, Elizabeth, et al.
Publicado: (2013)

Deoxycytidine Kinase Augments ATM-Mediated DNA Repair and Contributes to Radiation Resistance
por: Bunimovich, Yuri L., et al.
Publicado: (2014)

Induction of apoptosis and ganoderic acid biosynthesis by cAMP signaling in Ganoderma lucidum
por: You, Bang-Jau, et al.
Publicado: (2017)

Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by Topical cAMP Manipulation
por: Amaro-Ortiz, Alexandra, et al.
Publicado: (2014)

Cyclic 3', 5'-AMP relay in dictyostelium discoideum. IV. Recovery of the cAMP signaling response after adaptation to cAMP
por: Dinauer, M, et al.
Publicado: (1980)

Cyclic 3', 5'-AMP relay dictyostelium discoideum. V. Adaptation of the cAMP signaling response during cAMP stimulation
por: Dinauer, M, et al.
Publicado: (1980)

Suppression of Virulence of Toxigenic Vibrio cholerae by Anethole through the Cyclic AMP (cAMP)-cAMP Receptor Protein Signaling System
por: Zahid, M. Shamim Hasan, et al.
Publicado: (2015)

Sir2 phosphorylation through cAMP-PKA and CK2 signaling inhibits the lifespan extension activity of Sir2 in yeast
por: Kang, Woo Kyu, et al.
Publicado: (2015)

Augmented cAMP Signaling by Co-Administration of Resveratrol and Curcumin: A Cellular Biosensor Kinetic Assessment
por: SAFAVIFAR, Farnaz, et al.
Publicado: (2019)

Imaging cAMP nanodomains in the heart
por: Chao, Ying-Chi, et al.
Publicado: (2019)

cAMP is an allosteric modulator of DNA-binding specificity in the cAMP receptor protein from Mycobacterium tuberculosis
por: Gárate, Fernanda, et al.
Publicado: (2021)

An Improved Genetically Encoded Fluorescent cAMP Indicator for Sensitive cAMP Imaging and Fast Drug Screening
por: Liu, Wenfeng, et al.
Publicado: (2022)

Subcellular distribution in cerebral cortex of two proteins phosphorylated by a cAMP-dependent protein kinase
Publicado: (1979)

The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser(358) in adipocytes
por: Henriksson, Emma, et al.
Publicado: (2012)

cAMP-EPAC-Dependent Regulation of Gephyrin Phosphorylation and GABA(A)R Trapping at Inhibitory Synapses
por: Niwa, Fumihiro, et al.
Publicado: (2019)

Downregulation of cAMP-Dependent Protein Kinase Inhibitor-b Promotes Preeclampsia by Decreasing Phosphorylated Akt
por: Liu, Chunfeng, et al.
Publicado: (2020)

Caput Ligation Renders Immature Mouse Sperm Motile and Capable to Undergo cAMP-Dependent Phosphorylation
por: Tourzani, Darya A., et al.
Publicado: (2021)

Cyclic 3',5'-AMP relay in Dictyostelium discoideum III. The relationship of cAMP synthesis and secretion during the cAMP signaling response
Publicado: (1980)

Direct regulation of the natural competence regulator gene tfoX by cyclic AMP (cAMP) and cAMP receptor protein (CRP) in Vibrios
por: Wu, Rui, et al.
Publicado: (2015)

Selective ATM inhibition augments radiation-induced inflammatory signaling and cancer cell death
por: Chiu, Li-Ya, et al.
Publicado: (2023)

Promotion of cAMP Responsive Element-Binding Protein Activity Ameliorates Radiation-Induced Suppression of Hippocampal Neurogenesis in Adult Mice
por: Kim, Joong-Sun, et al.
Publicado: (2010)

ATM is the primary kinase responsible for phosphorylation of Hsp90α after ionizing radiation
por: Elaimy, Ameer L., et al.
Publicado: (2016)

Regulation of Inositol 1,4,5-Trisphosphate Receptors by cAMP Independent of cAMP-dependent Protein Kinase
por: Tovey, Stephen C., et al.
Publicado: (2010)

Activation of PKA in cell requires higher concentration of cAMP than in vitro: implications for compartmentalization of cAMP signalling
por: Koschinski, Andreas, et al.
Publicado: (2017)

Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in Trypanosoma brucei
por: Bachmaier, Sabine, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_vobg7fg2qgv30u6r2ff1jhqpf4