MUC16 mucin (CA125) attenuates TRAIL-induced apoptosis by decreasing TRAIL receptor R2 expression and increasing c-FLIP expression

BACKGROUND: MUC16 (CA125) is a large transmembrane mucin protein (> 200 kDa) aberrantly expressed in approximately 80% of human epithelial ovarian cancers (EOC). MUC16 expression in EOC cells is associated with increased tumorigenesis and inhibiton of genotoxic drug-induced apoptosis. However, th...

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Detalles Bibliográficos
Autores principales: Matte, Isabelle, Lane, Denis, Boivin, Marianne, Rancourt, Claudine, Piché, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234371/
https://www.ncbi.nlm.nih.gov/pubmed/24690311
http://dx.doi.org/10.1186/1471-2407-14-234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234371/
https://www.ncbi.nlm.nih.gov/pubmed/24690311
http://dx.doi.org/10.1186/1471-2407-14-234

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