The Efficacy of the Ribonucleotide Reductase Inhibitor Didox in Preclinical Models of AML

Acute Myeloid Leukemia (AML) is an aggressive malignancy which leads to marrow failure, and ultimately death. There is a desperate need for new therapeutics for these patients. Ribonucleotide reductase (RR) is the rate limiting enzyme in DNA synthesis. Didox (3,4-Dihydroxybenzohydroxamic acid) is a...

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Detalles Bibliográficos
Autores principales: Cook, Guerry J., Caudell, David L., Elford, Howard L., Pardee, Timothy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234372/
https://www.ncbi.nlm.nih.gov/pubmed/25402485
http://dx.doi.org/10.1371/journal.pone.0112619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234372/
https://www.ncbi.nlm.nih.gov/pubmed/25402485
http://dx.doi.org/10.1371/journal.pone.0112619

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