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The Efficacy of the Ribonucleotide Reductase Inhibitor Didox in Preclinical Models of AML
Acute Myeloid Leukemia (AML) is an aggressive malignancy which leads to marrow failure, and ultimately death. There is a desperate need for new therapeutics for these patients. Ribonucleotide reductase (RR) is the rate limiting enzyme in DNA synthesis. Didox (3,4-Dihydroxybenzohydroxamic acid) is a...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234372/ https://www.ncbi.nlm.nih.gov/pubmed/25402485 http://dx.doi.org/10.1371/journal.pone.0112619 |