Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein

[Image: see text] We herein report the design and synthesis of the first nanomolar binding inhibitor of STAT5 protein. Lead compound 13a, possessing a phosphotyrosyl-mimicking salicylic acid group, potently and selectively binds to STAT5 over STAT3, inhibits STAT5–SH2 domain complexation events in v...

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Detalles Bibliográficos
Autores principales: Cumaraswamy, Abbarna A., Lewis, Andrew M., Geletu, Mulu, Todic, Aleksandra, Diaz, Diego B., Cheng, Xin Ran, Brown, Carla E., Laister, Rob C., Muench, David, Kerman, Kagan, Grimes, H. Leighton, Minden, Mark D., Gunning, Patrick T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234445/
https://www.ncbi.nlm.nih.gov/pubmed/25419444
http://dx.doi.org/10.1021/ml500165r

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234445/
https://www.ncbi.nlm.nih.gov/pubmed/25419444
http://dx.doi.org/10.1021/ml500165r

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