Cargando…

Discovery of Potent and Specific Dihydroisoxazole Inhibitors of Human Transglutaminase 2

[Image: see text] Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme that catalyzes the posttranslational modification of glutamine residues on protein or peptide substrates. A growing body of literature has implicated aberrantly regulated activity of TG2 in the pathogenesis of various huma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Klöck, Cornelius, Herrera, Zachary, Albertelli, Megan, Khosla, Chaitan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234452/ https://www.ncbi.nlm.nih.gov/pubmed/25333388 http://dx.doi.org/10.1021/jm501145a

Ejemplares similares

Dihydroisoxazole inhibitors of Anopheles gambiae seminal transglutaminase AgTG3
por: Le, Binh V, et al.
Publicado: (2014)

Activation and Inhibition of Transglutaminase 2 in Mice
por: Dafik, Laila, et al.
Publicado: (2012)

Transglutaminase 2 Undergoes a Large Conformational Change upon Activation
por: Pinkas, Daniel M, et al.
Publicado: (2007)

Extracellular Transglutaminase 2 Is Catalytically Inactive, but Is Transiently Activated upon Tissue Injury
por: Siegel, Matthew, et al.
Publicado: (2008)

Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B
por: Meleddu, Rita, et al.
Publicado: (2017)

Tetrahydroquinoline/4,5‐Dihydroisoxazole Molecular Hybrids as Inhibitors of Breast Cancer Resistance Protein (BCRP/ABCG2)
por: Vesga, Luis C., et al.
Publicado: (2021)

Cell-Impermeable Inhibitors Confirm That Intracellular Human Transglutaminase 2 Is Responsible for the Transglutaminase-Associated Cancer Phenotype
por: Gates, Eric W. J., et al.
Publicado: (2023)

Discovery of a microbial transglutaminase enabling highly site-specific labeling of proteins
por: Steffen, Wojtek, et al.
Publicado: (2017)

Discovery and Characterization of PROTACs Targeting Tissue Transglutaminase (TG2)
por: Valdivia, Andres, et al.
Publicado: (2023)

Regiospecific formation of the nitromethyl-substituted 3-phenyl-4,5-dihydroisoxazole via [3 + 2] cycloaddition
por: Mirosław, Barbara, et al.
Publicado: (2018)

Transglutaminase 2 in human diseases
por: Szondy, Zsuzsa, et al.
Publicado: (2017)

Transglutaminase 2—a novel inhibitor of adipogenesis
por: Myneni, V D, et al.
Publicado: (2015)

3,5-Bis(4-methoxyphenyl)-4,5-dihydroisoxazole
por: Samshuddin, S., et al.
Publicado: (2011)

Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2
por: Song, Yun-Qing, et al.
Publicado: (2021)

Effects of 3‐Bromo‐4,5‐dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase‐1 Expression
por: Pinto, Andrea, et al.
Publicado: (2018)

Discovery of a novel target for renal cell carcinoma: transglutaminase 2
por: Kang, J H, et al.
Publicado: (2016)

(S)-[5-Methyl-3-(3-methylthiophen-2-yl)-4,5-dihydroisoxazol-5-yl]methanol
por: Ko, Young Kwan, et al.
Publicado: (2011)

Synthesis of 3-substituted isoxazolidin-4-ols using hydroboration–oxidation reactions of 4,5-unsubstituted 2,3-dihydroisoxazoles
por: Dikošová, Lívia, et al.
Publicado: (2020)

Novel Synthesis of Dihydroisoxazoles by p-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones
por: Yang, Caiyun, et al.
Publicado: (2023)

(2-tert-Butyl-3-phenyl-2,3-dihydroisoxazole-4,5-diyl)bis(phenylmethanone)
por: Sandhya, R., et al.
Publicado: (2013)

Parallels between Pathogens and Gluten Peptides in Celiac Sprue
por: Bethune, Michael T, et al.
Publicado: (2008)

Genomic mining and diversity of assembly line polyketide synthases
por: Kishore, Shreya, et al.
Publicado: (2023)

Cystamine and cysteamine as inhibitors of transglutaminase activity in vivo
por: Jeitner, Thomas M., et al.
Publicado: (2018)

GRINS: Genetic elements that recode assembly-line polyketide synthases and accelerate their diversification
por: Nivina, Aleksandra, et al.
Publicado: (2021)

1′,3′,3′-Trimethyl-2,3-diphenyl-2,3-dihydroisoxazole-5(4H)-spiro-2′-indoline
por: Laghrib, Naoual, et al.
Publicado: (2009)

Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome
por: Forsberg, Kevin J, et al.
Publicado: (2019)

Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1
por: Zhang, Jing, et al.
Publicado: (2022)

QSAR Accelerated Discovery of Potent Ice Recrystallization Inhibitors
por: Briard, Jennie G., et al.
Publicado: (2016)

Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors
por: Cuffaro, Doretta, et al.
Publicado: (2021)

Discovery and characterization of potent And‐1 inhibitors for cancer treatment
por: Li, Jing, et al.
Publicado: (2021)

Discovery of potent and specific inhibitors targeting the active site of MMP-9 from the engineered SPINK2 library
por: Yano, Hidenori, et al.
Publicado: (2020)

Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout
por: Tan, Philip K., et al.
Publicado: (2017)

Bioassay-Guided Evolution of Glycosylated Macrolide Antibiotics in Escherichia coli
por: Lee, Ho Young, et al.
Publicado: (2007)

Challenges and opportunities for engineering assembly-line polyketide biosynthesis in Escherichia coli
por: Yuet, Kai P., et al.
Publicado: (2019)

Fragment antigen binding domains (F(ab)s) as tools to study assembly-line polyketide synthases
por: Guzman, Katarina M., et al.
Publicado: (2021)

Genomic variants reveal differential evolutionary constraints on human transglutaminases and point towards unrecognized significance of transglutaminase 2
por: Thangaraju, Kiruphagaran, et al.
Publicado: (2017)

A Novel Therapeutic Target in Inflammatory Uveitis: Transglutaminase 2 Inhibitor
por: Sohn, Joonhong, et al.
Publicado: (2010)

New Insights into Development of Transglutaminase 2 Inhibitors as Pharmaceutical Lead Compounds
por: Kim, Soo-Youl
Publicado: (2018)

Discovery and identification of O, O-diethyl O-(4-(5-phenyl-4, 5-dihydroisoxazol-3-yl) phenyl) phosphorothioate (XP-1408) as a novel mode of action of organophosphorus insecticides
por: Zeng, Zhigang, et al.
Publicado: (2017)

Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors
por: Giovannuzzi, Simone, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bq2f0sqtneej4o4eumr6t8h5c3