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Conservancy of mAb Epitopes in Ebolavirus Glycoproteins of Previous and 2014 Outbreaks

Background: Several monoclonal antibodies (mAb) are being evaluated as treatment options for the current 2014 Ebola outbreak. But they were derived from and tested for protection against the older 1976 Mayinga or 1995 Kikwit Zaire Ebolaviruses (EBOV). The EBOV sequences reported for the current outb...

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Detalles Bibliográficos
Autores principales: Ponomarenko, Julia, Vaughan, Kerrie, Sette, Alessandro, Maurer-Stroh, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234462/
https://www.ncbi.nlm.nih.gov/pubmed/25642381
http://dx.doi.org/10.1371/currents.outbreaks.f1a7028a13ce1c5f0bdbb4b0cc0b919b