Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells

BACKGROUND: The endosteum of the bone marrow provides a specialized hypoxic niche that may serve to preserve the integrity, pluripotency, longevity and stemness of resident mesenchymal stem cells (MSCs). To explore the molecular genetic consequences of such a niche we subjected human (h) MSCs to a p...

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Detalles Bibliográficos
Autores principales: Hu, Xinyang, Wu, Rongrong, Shehadeh, Lina A, Zhou, Qing, Jiang, Cizhong, Huang, Xin, Zhang, Ling, Gao, Feng, Liu, Xianbao, Yu, Hong, Webster, Keith A, Wang, Jian’an
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234502/
https://www.ncbi.nlm.nih.gov/pubmed/24758227
http://dx.doi.org/10.1186/1471-2164-15-303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234502/
https://www.ncbi.nlm.nih.gov/pubmed/24758227
http://dx.doi.org/10.1186/1471-2164-15-303

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