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Upregulation of TPX2 by STAT3: Identification of a Novel STAT3 Binding Site

TPX2, a protein involved in mitosis, is considered a good marker for actively proliferating tissues, highly expressed in a number of cancer cells. We show the presence of high-affinity binding site for STAT3 in the 5′-flanking region of the Tpx2 gene, which is in vivo bound by activated STAT3. A spe...

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Detalles Bibliográficos
Autores principales: Cocchiola, Rossana, Grillo, Caterina, Altieri, Fabio, Chichiarelli, Silvia, Turano, Carlo, Eufemi, Margherita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234655/
https://www.ncbi.nlm.nih.gov/pubmed/25401333
http://dx.doi.org/10.1371/journal.pone.0113096