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Defining the Role of Oxygen Tension in Human Neural Progenitor Fate
Hypoxia augments human embryonic stem cell (hESC) self-renewal via hypoxia-inducible factor 2α-activated OCT4 transcription. Hypoxia also increases the efficiency of reprogramming differentiated cells to a pluripotent-like state. Combined, these findings suggest that low O(2) tension would impair th...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235163/ https://www.ncbi.nlm.nih.gov/pubmed/25418722 http://dx.doi.org/10.1016/j.stemcr.2014.09.021 |