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Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells

Leptin is a circulating hormone that plays a critical role in regulating energy expenditure and food intake. Evidence to suggest the involvement of endoplasmic reticulum (ER) stress in the development of obesity is increasing. To adapt against ER stress, cells trigger the unfolded protein response (...

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Detalles Bibliográficos
Autores principales: Thon, Mina, Hosoi, Toru, Yoshii, Michiko, Ozawa, Koichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235288/
https://www.ncbi.nlm.nih.gov/pubmed/25403445
http://dx.doi.org/10.1038/srep07096