Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease

Type 2 diabetes (T2D) is a major risk factor for late-onset Alzheimer's disease (AD). A variety of metabolic changes related to T2D (e.g. hyperinsulinemia, hyperglycemia, and elevated branched-chain amino acids) have been proposed as mechanistic links, but the basis for this association remains...

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Detalles Bibliográficos
Autores principales: Morabito, Michael V., Berman, Diego E., Schneider, Remy T., Zhang, Yiying, Leibel, Rudolph L., Small, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235335/
https://www.ncbi.nlm.nih.gov/pubmed/24440570
http://dx.doi.org/10.1016/j.nbd.2013.12.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235335/
https://www.ncbi.nlm.nih.gov/pubmed/24440570
http://dx.doi.org/10.1016/j.nbd.2013.12.017

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