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Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease
Type 2 diabetes (T2D) is a major risk factor for late-onset Alzheimer's disease (AD). A variety of metabolic changes related to T2D (e.g. hyperinsulinemia, hyperglycemia, and elevated branched-chain amino acids) have been proposed as mechanistic links, but the basis for this association remains...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235335/ https://www.ncbi.nlm.nih.gov/pubmed/24440570 http://dx.doi.org/10.1016/j.nbd.2013.12.017 |