Cargando…
A Functional Selectivity Mechanism at the Serotonin-2A GPCR Involves Ligand-Dependent Conformations of Intracellular Loop 2
[Image: see text] With recent progress in determination of G protein-coupled receptor (GPCR) structure with crystallography, a variety of other experimental approaches (e.g., NMR spectroscopy, fluorescent-based assays, mass spectrometry techniques) are also being used to characterize state-specific...
Autores principales: | Perez-Aguilar, Jose Manuel, Shan, Jufang, LeVine, Michael V., Khelashvili, George, Weinstein, Harel |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235374/ https://www.ncbi.nlm.nih.gov/pubmed/25314362 http://dx.doi.org/10.1021/ja508394x |
Ejemplares similares
-
Ligand-Dependent Conformations and Dynamics of the Serotonin 5-HT(2A) Receptor Determine Its Activation and Membrane-Driven Oligomerization Properties
por: Shan, Jufang, et al.
Publicado: (2012) -
Ligand modulation of sidechain dynamics in a wild-type human GPCR
por: Clark, Lindsay D, et al.
Publicado: (2017) -
The Membrane Protein LeuT in Micellar Systems: Aggregation
Dynamics and Detergent Binding to the S2 Site
por: Khelashvili, George, et al.
Publicado: (2013) -
Autoregulation of GPCR signalling through the third intracellular loop
por: Sadler, Fredrik, et al.
Publicado: (2023) -
A partially-open inward-facing intermediate conformation of LeuT is associated with Na(+) release and substrate transport
por: Terry, Daniel S., et al.
Publicado: (2018)