TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends

Telomeres protect the ends of linear genomes, and the gradual loss of telomeres is associated with cellular ageing. Telomere protection involves the insertion of the 3′ overhang facilitated by telomere repeat-binding factor 2 (TRF2) into telomeric DNA, forming t-loops. We present evidence suggesting...

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Detalles Bibliográficos
Autores principales: Wood, Ashley M., Danielsen, Jannie M. Rendtlew, Lucas, Catherine A., Rice, Ellen L., Scalzo, David, Shimi, Takeshi, Goldman, Robert D., Smith, Erica D., Le Beau, Michelle M., Kosak, Steven T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235626/
https://www.ncbi.nlm.nih.gov/pubmed/25399868
http://dx.doi.org/10.1038/ncomms6467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235626/
https://www.ncbi.nlm.nih.gov/pubmed/25399868
http://dx.doi.org/10.1038/ncomms6467

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