Hrd1-mediated BLIMP-1 ubiquitination promotes dendritic cell MHCII expression for CD4 T cell priming during inflammation

The ubiquitin pathway plays critical roles in antigen presentation. However, the ubiquitin ligases that regulate MHC gene transcription remain unidentified. We showed that the ubiquitin ligase Hrd1, expression of which is induced by Toll-like receptor (TLR) stimulation, is required for MHC-II but no...

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Detalles Bibliográficos
Autores principales: Yang, Heeyoung, Qiu, Quan, Gao, Beixue, Kong, Sinyi, Lin, Zhenghong, Fang, Deyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235642/
https://www.ncbi.nlm.nih.gov/pubmed/25366967
http://dx.doi.org/10.1084/jem.20140283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235642/
https://www.ncbi.nlm.nih.gov/pubmed/25366967
http://dx.doi.org/10.1084/jem.20140283

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