PDGF receptor alpha inhibition induces apoptosis in glioblastoma cancer stem cells refractory to anti-Notch and anti-EGFR treatment

BACKGROUND: Cancer stem cells (CSC) represent a rare fraction of cancer cells characterized by resistance to chemotherapy and radiation, therefore nowadays there is great need to develop new targeted therapies for brain tumors and our study aim to target pivotal transmembrane receptors such as Notch...

Descripción completa

Detalles Bibliográficos
Autores principales: Cenciarelli, Carlo, Marei, Hany ES, Zonfrillo, Manuela, Pierimarchi, Pasquale, Paldino, Emanuela, Casalbore, Patrizia, Felsani, Armando, Vescovi, Angelo Luigi, Maira, Giulio, Mangiola, Annunziato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235989/
https://www.ncbi.nlm.nih.gov/pubmed/25380967
http://dx.doi.org/10.1186/1476-4598-13-247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235989/
https://www.ncbi.nlm.nih.gov/pubmed/25380967
http://dx.doi.org/10.1186/1476-4598-13-247

Ejemplares similares