Activation of the NLRP3 Inflammasome Complex is Not Required for Stress-Induced Death of Pancreatic Islets

Loss of pancreatic beta cells is a feature of type-2 diabetes. High glucose concentrations induce endoplasmic reticulum (ER) and oxidative stress-mediated apoptosis of islet cells in vitro. ER stress, oxidative stress and high glucose concentrations may also activate the NLRP3 inflammasome leading t...

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Detalles Bibliográficos
Autores principales: Wali, Jibran A., Gurzov, Esteban N., Fynch, Stacey, Elkerbout, Lorraine, Kay, Thomas W., Masters, Seth L., Thomas, Helen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236141/
https://www.ncbi.nlm.nih.gov/pubmed/25405767
http://dx.doi.org/10.1371/journal.pone.0113128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236141/
https://www.ncbi.nlm.nih.gov/pubmed/25405767
http://dx.doi.org/10.1371/journal.pone.0113128

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