Cargando…

Activation of the NLRP3 Inflammasome Complex is Not Required for Stress-Induced Death of Pancreatic Islets

Loss of pancreatic beta cells is a feature of type-2 diabetes. High glucose concentrations induce endoplasmic reticulum (ER) and oxidative stress-mediated apoptosis of islet cells in vitro. ER stress, oxidative stress and high glucose concentrations may also activate the NLRP3 inflammasome leading t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wali, Jibran A., Gurzov, Esteban N., Fynch, Stacey, Elkerbout, Lorraine, Kay, Thomas W., Masters, Seth L., Thomas, Helen E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236141/ https://www.ncbi.nlm.nih.gov/pubmed/25405767 http://dx.doi.org/10.1371/journal.pone.0113128

Ejemplares similares

The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity
por: Wali, J A, et al.
Publicado: (2014)

Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice
por: Trivedi, Prerak M., et al.
Publicado: (2019)

IL-17F induces inflammation, dysfunction and cell death in mouse islets
por: Catterall, Tara, et al.
Publicado: (2020)

NLRP3 Inflammasome is Activated in Rat Pancreatic Islets by Transplantation and Hypoxia
por: Lavallard, Vanessa, et al.
Publicado: (2020)

Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System
por: Litwak, Sara A., et al.
Publicado: (2015)

NLRP3 inflammasome is expressed and regulated in human islets
por: Lebreton, Fanny, et al.
Publicado: (2018)

Linking Metabolic Abnormalities to Apoptotic Pathways in Beta Cells in Type 2 Diabetes
por: Wali, Jibran A., et al.
Publicado: (2013)

IL-21 regulates SOCS1 expression in autoreactive CD8(+) T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice
por: Sutherland, Andrew P. R., et al.
Publicado: (2019)

Activation of NLRP3 Inflammasome by Advanced Glycation End Products Promotes Pancreatic Islet Damage
por: Kong, Xiang, et al.
Publicado: (2017)

Inhibition of NLRP3 inflammasome by MCC950 improves the metabolic outcome of islet transplantation by suppressing IL-1β and islet cellular death
por: Matsuoka, Taisuke, et al.
Publicado: (2020)

Pancreatic Alpha Cells Hold the Key to Survival
por: Wali, Jibran A., et al.
Publicado: (2015)

Pancreatic β-Cell Membrane Fluidity and Toxicity Induced by Human Islet Amyloid Polypeptide Species
por: Pilkington, Emily H., et al.
Publicado: (2016)

Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction
por: Chevriaux, Angélique, et al.
Publicado: (2020)

The trigger for pancreatic disease: NLRP3 inflammasome
por: Liu, Tianming, et al.
Publicado: (2023)

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
por: Lawlor, Kate E., et al.
Publicado: (2015)

IKKβ is required for the formation of the NLRP3 inflammasome
por: Nanda, Sambit K, et al.
Publicado: (2021)

NLRP3 Inflammasome-Mediated Inflammation in Acute Pancreatitis
por: Ferrero-Andrés, Ana, et al.
Publicado: (2020)

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii
por: Gorfu, Gezahegn, et al.
Publicado: (2014)

Inhibition of Y1 receptor signaling improves islet transplant outcome
por: Loh, Kim, et al.
Publicado: (2017)

p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity.
por: Litwak, Sara A., et al.
Publicado: (2016)

Proteolytic Processing of Nlrp1b Is Required for Inflammasome Activity
por: Frew, Bradley C., et al.
Publicado: (2012)

Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation
por: de la Roche, Marianne, et al.
Publicado: (2018)

Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation
por: Lin, Hsin-Chung, et al.
Publicado: (2021)

The NLRP3 Inflammasome Is Required for Protection Against Pseudomonas Keratitis
por: Ramadan, Abdulraouf, et al.
Publicado: (2023)

Islet β-Cells Deficient in Bcl-xL Develop but Are Abnormally Sensitive to Apoptotic Stimuli
por: Carrington, Emma M., et al.
Publicado: (2009)

The NLRP6 inflammasome
por: Zheng, Danping, et al.
Publicado: (2020)

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome
por: Levinsohn, Jonathan L., et al.
Publicado: (2012)

Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation
por: Lang, Tali, et al.
Publicado: (2018)

The leucine-rich repeat (LRR) domain of NLRP3 is required for NLRP3 inflammasome activation in macrophages
por: Duan, Yanhui, et al.
Publicado: (2022)

ER stress induces NLRP3 inflammasome activation and hepatocyte death
por: Lebeaupin, C, et al.
Publicado: (2015)

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke
por: Yang-Wei Fann, D, et al.
Publicado: (2013)

PCB118 Induces Inflammation of Islet Beta Cells via Activating ROS-NLRP3 Inflammasome Signaling
por: Jiang, Chunxia, et al.
Publicado: (2021)

Lymphangiogenesis Is Required for Pancreatic Islet Inflammation and Diabetes
por: Yin, Na, et al.
Publicado: (2011)

The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin–Induced Diabetes in Mice
por: Chia, Joanne S.J., et al.
Publicado: (2013)

Inhibiting the NLRP3 Inflammasome
por: El-Sharkawy, Lina Y., et al.
Publicado: (2020)

The NLRP3 inflammasome in macrophages is stimulated by cell‐free hemoglobin
por: Shaver, Ciara M., et al.
Publicado: (2020)

The Role of the NLRP3 Inflammasome and Programmed Cell Death in Acute Liver Injury
por: Yu, Chaoqun, et al.
Publicado: (2023)

MARCH5‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7 complex formation and NLRP3 inflammasome activation
por: Park, Yeon‐Ji, et al.
Publicado: (2023)

Bergenin inhibits palmitic acid-induced pancreatic β-cell inflammatory death via regulating NLRP3 inflammasome activation
por: Lei, Donghong, et al.
Publicado: (2022)

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death
por: Arif, Sefina, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_a0146eb6lc4t35pqr7neeisu5r