Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease

How stage-specific enhancer dynamics modulate gene expression patterns essential for organ development, homesostasis, and disease is not well understood. Here, we addressed this question by mapping chromatin occupancy of GATA4—a master cardiac transcription factor—in heart development and disease. W...

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Detalles Bibliográficos
Autores principales: He, Aibin, Gu, Fei, Hu, Yong, Ma, Qing, Yi Ye, Lillian, Akiyama, Jennifer A., Visel, Axel, Pennacchio, Len A., Pu, William T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236193/
https://www.ncbi.nlm.nih.gov/pubmed/25249388
http://dx.doi.org/10.1038/ncomms5907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236193/
https://www.ncbi.nlm.nih.gov/pubmed/25249388
http://dx.doi.org/10.1038/ncomms5907

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