Analysis of the quantitative balance between insulin-like growth factor (IGF)-1 ligand, receptor, and binding protein levels to predict cell sensitivity and therapeutic efficacy

BACKGROUND: The insulin-like growth factor (IGF) system impacts cell proliferation and is highly activated in ovarian cancer. While an attractive therapeutic target, the IGF system is complex with two receptors (IGF1R, IGF2R), two ligands (IGF1, IGF2), and at least six high affinity IGF-binding prot...

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Detalles Bibliográficos
Autores principales: Tian, Dan, Kreeger, Pamela K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236724/
https://www.ncbi.nlm.nih.gov/pubmed/25115504
http://dx.doi.org/10.1186/s12918-014-0098-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236724/
https://www.ncbi.nlm.nih.gov/pubmed/25115504
http://dx.doi.org/10.1186/s12918-014-0098-y

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