HMM-ModE: implementation, benchmarking and validation with HMMER3

BACKGROUND: HMM-ModE is a computational method that generates family specific profile HMMs using negative training sequences. The method optimizes the discrimination threshold using 10 fold cross validation and modifies the emission probabilities of profiles to reduce common fold based signals share...

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Detalles Bibliográficos
Autores principales: Sinha, Swati, Lynn, Andrew Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236727/
https://www.ncbi.nlm.nih.gov/pubmed/25073805
http://dx.doi.org/10.1186/1756-0500-7-483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236727/
https://www.ncbi.nlm.nih.gov/pubmed/25073805
http://dx.doi.org/10.1186/1756-0500-7-483

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